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doi: 10.2337/dc15-2727 277 HardingJJGaneaE

Collagen is the most abundant protein in the human body, serving as the primary structural framework for skin, bones, tendons, ligaments, and the endothelial lining of blood vessels

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By designing a thiol-activatable fluorescent gold nanoprobe that can bind to serum protein and be transported to the liver, we non-invasively imaged the biotransformation kinetics in vivo at high specificity and examined this process at the chemical level