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Excessive APAP metabolism depletes glutathione and increases N-acetyl-p-benzoquinoneimide (NAPQI) levels, leading to oxidative stress, DNA damage, and cell necrosis in the liver, which in turn leads to liver damage

Just one involved human subjects

There was no significant difference in the incidence of adverse events and serious adverse events in patients with diabetic neuropathy who took 600 mg/day of lipoic acid for four years compared to those in the placebo group (78)

[PMID: 6854910] PubMed record related to this compound for laboratory literature review

Expanded field OCT angiography biomarkers for predicting clinically significant outcomes in non-proliferative diabetic retinopathy