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Consistently, overexpression of hHPN WT in hepsin / mice resulted in a significant increase in APAP tolerance, with survival rates exceeding 80% even after 80 h (Fig

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L-Buthionine sulfoximine (BSO) is a specific -glutamylcysteine synthetase inhibitor that blocks the rate-limiting step of glutathionine (GSH) biosynthesis and in doing so depletes the intracellular GSH pool in both cultured cells and in whole animals [10]

doi: 10.3390/pharmaceutics15122717 16 SuWLiYYangGZhaoYZhouXLiuG

[55] have formulated liposomes loaded with dexamethasone palmitate (DXP), a prodrug of dexamethasone, ranging in size from 100 nm to 30 m, and contrasted their efficacy to a suspension containing DXP and TAC

Upon intravenous injection, the nanoreactors selectively accumulate in the tumor and nearly fully eradicated an aggressive osteosarcoma inside a mouse model