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Sirtuins are a family of 7 enzymes (SIRT1 to SIRT7) that use the NAD + as a co-substrate for their deacetylation activity
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Since PRDX2 has been shown to be glutathionylated by GSH at its cysteine residues to protect against its hyperperoxidation 41 , it is possible that elevated GSH levels in T315I-Bcr-Abl cells might prevent PRDX2 monomer formation, therefore abrogating ROS-induced replication stress
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10.1002/cbic.201200556 Chembiochem 81 ViaeneJ.TielsP.LoggheM.DewaeleS.MartinetW.ContrerasR
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