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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
In the 1990s and 2000s, further non-RCT studies in the elderly with or without dementia/AD and low B12 status have also mostly shown no benefit of B12 for cognitive function
, Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis, Elsevier BV, Jul
Despite a lack of evidence, some people claim they help recovery, fat loss or antiageing
However, their ability to dramatically improve metabolic health markers (insulin sensitivity, visceral fat, inflammation) addresses major drivers of biological aging
According to doctors, the combination of antidepressants and vitamin B12 leads to an improvement in the condition of patients with depression compared to taking medication alone
