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Citicoline also appeared to limit memory deficits and the duration and severity of other post-traumatic symptoms (e.g., headache, dizziness, attention disorder) in TBI patients with mild-to-moderate injuries (GCS scores, 9-15) (reviewed in 5)

Further research is needed to understand whether this transition is driven by biochemical cues associated with localized hypoxia within the fibrotic regions, mechanical cues arising from local tissue stiffening, or a combination of both