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MIA, an inhibitor of glyceraldehyde-3-phosphate dehydrogenase, can disrupt chondrocyte glycolysis and ultimately lead to cell death, thereby contributing to cartilage degradation, subsequent alterations in subchondral bone, and the development of osteophytes 25,34
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Do not take other GLP-1 agonists (such as Ozempic or Zepbound) with Mounjaro because they work through similar pathways and can significantly increase the risk of side effects such as nausea, vomiting, diarrhea, and low blood sugar levels without offering any added benefit
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Even modest increases in daily movementsuch as walkingcontribute meaningfully to outcomes