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Data suggest the requirement of GLP1 receptors in both the vagal afferents as well as the brain for the full effects of GLP1 receptor agonists on energy balance, with the hypothalamus being the primary downstream target of peripherally administered GLP1 receptor agonists

3.2 Benefits of a ketogenic diet in the adult brain Ketones also contribute uniquely to the maturation of the nervous system by promoting myelin formation

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A Systematic Review of the Effect of Semaglutide on Lean Mass: Insights from Clinical Trials. Expert Opinion on Pharmacotherapy , 25(5), 611-619, 2024

When to talk to a healthcare provider Only take GLP-1s alongside the guidance of a healthcare provider, and with regular touchpoints where you can talk to that provider about your symptoms