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Piccinini-Vallis H, Woolcott C, Miller L, Snelgrove-Clarke E, Cahill S

When to speak to your GP Contact your GP or prescriber if you experience: Persistent stomach pain, especially if youre taking NSAIDs regularly Blood in your vomit or stools, or black tarry stools Severe constipation that doesnt respond to increased fluids and fibre, particularly if youre also taking codeine Reduced urine output or dark-coloured urine, which could suggest dehydration or kidney strain Pain that isnt adequately controlled by over-the-counter painkillers Severe nausea or vomiting that prevents you from taking your regular medications Any new or worsening side effects after starting a painkiller alongside Wegovy Regular painkiller use for a chronic condition that hasnt been reviewed recently If you experience severe abdominal pain, vomiting blood, or signs of bowel obstruction (complete inability to pass wind or stools with severe bloating), seek urgent medical attention

The IV route remains the most efficient way to deliver clinically meaningful doses