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Importantly, however, particle design governs risk: surface-displayed antigens or certain chemistries can raise immunogenicity and, in rare cases, provoke severe hypersensitivity (including anaphylaxis), whereas encapsulation strategies tend to blunt immediate antigen recognition and are therefore often safer in vivo (206, 208)

Ultraviolet radiation increases generation of reactive oxygen and nitrogen species, which in turn enhance tyrosinase activity and thereby synthesis of melanin species within cells

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