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While many individuals can benefit from B12 injections, certain groups may see more significant or rapid improvements: Vegetarians and Vegans Plant-based diets are often low in B12, making supplementation crucial

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Aqueous solvents such as sterile water or bacteriostatic water are preferred for in vivo rodent studies because they eliminate the confounding variable of DMSO's own biological activity, which includes membrane permeabilization and anti-inflammatory effects

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They are extrapolated from animal study endpoints and community discussion