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(5) current research must focus on the development of drugs that penetrate the BBB, facilitate cognitive processing, and protect against the loss of synapses and neurons

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In contrast, subacute etiologies (idiosyncratic DILI, indeterminate causes) involve ongoing, smoldering hepatocyte destruction over weeks, which continuously undermines the regenerative response

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The metabolic alterations in OC tissue included elevated glycolysis (lactic acid) and TCA cycle intermediates (malic acid, fumaric acid) were related to energy metabolism

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