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Central GLP-1 receptor activation is highest when semaglutide levels peak in the bloodstream, typically in the days following injection
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Population Pharmacokinetic Modelling Datasets containing plasma concentration and covariate data from each trial were converted to a format compatible with the nonlinear mixed-effects modelling (NONMEM) software (ICON Development Solutions, Ellicott City, MD, USA), version 7.1.2
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