The actual future market size will likely be highly impacted by whether GLP-1RAs end up being used as longer-term treatments for individuals and how costs and pricing evolve over time
In the STEP 1 trial, about 74% of participants on semaglutide experienced GI side effects (nausea, vomiting, diarrhea, or constipation) (source)
There are several reasons why people may experience leg cramps while taking semaglutide
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Critically, the study lacked a placebo group [7][31]
Thieu VT, Robinson S, Kennedy-Martin T, Boye KS, Garcia-Perez LE