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An inadequate or excessive compensatory adaptive response, termed malacclimatization, can impair oxygen delivery, leading to hypoxemia, which is defined as a decrease in the arterial partial pressure of oxygen (PaO)

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Moreover, although short-term management seems promising, long-term management of agitation and aggression requires further investigation (Ballard and Corbett, 2013) and may require a combination of pharmacological and non-pharmacological approaches (Koenig et al., 2016)

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