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Treatment should only be continued if there is a beneficial metabolic response (reduction of at least 11 mmol/mol [1%] in HbA1c and weight loss of at least 3% of initial body weight in 6 months)

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L., Duclos, Q., & Blesso, C

[11] The hypothesis underlying microdosing is that lower doses might provide some metabolic benefit whilst minimising these troublesome symptoms, potentially improving treatment adherence