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This dysregulation may have downstream effects on the gut microbiome, which is known to exhibit high levels of dysbiosis in ME/CFS patients (Morten et al., 2018

293,294 Several new RNA therapeutics are in late-stage clinical trials, such as mRNA-1944 (NCT03829384) 295 and NTLA-2001 (NCT06128629)

This leads to the release and cytoplasmic translocation of p53, which can subsequently activate transcription-independent pro-apoptotic signaling (Figures 6A,B)

2017;Sep:18

rs12325817) of the PEMT gene, which may affect the expression and/or activity of the PEMT enzyme, is thought to increase the susceptibility to choline deficiency-induced organ dysfunction (18)

Transcriptome analysis of watermelon ( Citrullus lanatus ) fruits in response to Cucumber green mottle mosaic virus (CGMMV) infection