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Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

So I will put a plug out there that I do not consider that to be an absolute no-no to a GLP, but it's just something that you have to speak with your doctor about to see if you're still a candidate

Existing research shows that menstrual changes (like heavier bleeding) can increase iron loss, which plays an important role in transporting oxygen and energy production

JAMA Neurology

Older Adults Older adults can use GLP-1 medications safely