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November 21, 2024

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A phase 2B clinical trial (HARMONY) revealed that efruxifermin, a bivalent Fc-FGF21 analog, improved hepatic inflammation and fibrosis over 24 weeks in patients with F2 or F3 fibrosis, with an acceptable safety profile, warranting further investigation in phase 3 trials (NCT04767529)

Future research should identify the dominant -synuclein epitopes, the timing of T-cell priming in relation to neurodegeneration, and which patient subgroups benefit most from immune-targeted therapies

Women on hormone therapy lost 16% of their body weight in a year compared to 12% without hormone therapy

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