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In a large clinical follow-up study, patients who discontinued semaglutide therapy regained approximately two-thirds of the weight they had lost within one year
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In another study, semaglutide exhibited greater potency in activating GLP-1R compared to GLP-1, with an EC50 of 6.2 pM for semaglutide vs 16.2 pM for GLP-1 (95) (The variability in EC50 values among different studies for GLP-1 was not uncommon attributable to varying assay conditions)
Your prescriber may also recommend an alternative if you have severe stomach or intestinal problems, pancreatitis, or other conditions that could make Mounjaro unsafe
However, semaglutide can influence certain blood test resultsincluding glucose, HbA1c, and lipid levelsdue to its therapeutic effects
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