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It works by binding directly to the IGF-1 receptor (IGF-1R) on muscle and other tissue, activating the PI3K/Akt and MAPK signaling cascades that drive cell growth and proliferation

Maquart and colleagues reported stimulation of collagen synthesis in fibroblast cultures by GHK-Cu, while later work connected GHK-Cu to matrix remodeling enzymes and inhibitors [4], [5]

Typically, if stored correctly in a freezer (around -20C or -4F), an unopened GHK-Cu vial can maintain its integrity for 1-2 years, sometimes even longer, depending on specific batch characteristics

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Roughly 90 per cent of drugs that show promise in animals ultimately fail in human trials