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This pattern holds across age groups, genders, and baseline fitness levels

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During his time at the hospital he suffered from two fractured ribs and three cardiac arrests and had several blood transfusions

The paradigm for treating people with obesity has often been to recommend lifestyle changes, and then if they develop diabetes or another metabolic condition, to treat them with metformin, insulin, or GLP-1 drugs, says study senior and corresponding author Andrew Stokes, associate professor of global health

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This is especially important because the wrong response to side effects can create a downward spiral: nausea leads to under-eating under-eating leads to weakness and poor protein intake poor intake and GI symptoms contribute to dehydration exercise tolerance drops patients lose weight, but not in a healthy or durable way A supervised plan helps interrupt that pattern early