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Experimental studies in both animals and humans have tried to confirm the findings from observational studies and reported that CLA exhibits numerous health benefits including anti-obesity, anti-carcinogenic, hypotensive, hypoglycemic, and immunomodulatory effects (table 2)
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More recently, machine learning models that combine metabolomic readouts with embryologic and imaging-derived variables have reported improved implantation prediction compared with single data streams, supporting late integration or stacked models under careful cross-validation and external replication [436]
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In summary, the development of NADs has undergone a long process, with research on the mechanisms of action of different types of drugs and breakthroughs in chemical modification and delivery technologies
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