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The substrates, glutamate and glycine, are often present in cells, but some cells lack sufficient cysteine to make additional glutathione
however, aggregates of TTR, including oligomeric forms, have previously been linked to cytotoxicity [81,82,83,84,85] supporting the possibility that misfolded TTR may contribute to this response
These symptoms tend to be heightened upon increase in dose and within the first two days of injection
Rask-Madsen C, King GL
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