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doi: 10.2337/diabetes.54.1.146 62
Interestingly, TIMP-2 knock out mice show deficits in fear potentiated startle (65)
Researchers frequently select DSIP when investigating sleep pathway activity because it is commonly associated with studies involving sleep regulation and neurological signaling
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Furthermore, a recent clinical study in women with obesity treated with semaglutide showed improved recognition of basic tastes, altered gene expression in the tongue (measured by tongue biopsy), decreased activation of putamen in response to calorie-dense sweet and savory food cues, and increased cortical brain activity in response to the sweet taste stimulus compared to placebo
It also supports aerobic metabolism in skeletal muscle and mitochondrial energy production, helping reduce fatigue during and after prolonged efforts
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