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These effects were generally mild to moderate in severity and tended to diminish over time as the body adapted
Also, there are nerves in the gut which can sense GLP-1 and signal back to the brain, so the picture is a lot more complicated and more research is being carried out into the way GLP-1 and GLP-1 mimetics work
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These include cases of pancreatitis and a potential association with thyroid C-cell tumors in rodent models