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In clinical research settings, this difference matters most in how each compound is measured: Tesamorelin has been studied in trials involving GH and IGF-1 level changes, while AOD-9604 research has focused specifically on lipolysis and fat oxidation markers without the same IGF-1 elevation a distinction documented in peer-reviewed pharmacology literature comparing hGH fragments to full GHRH analogs

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Open question Whether the same mechanisms are clinically meaningful in humans is not yet established

[5] Iyer KS, Marks GA, Kastin AJ, McCann SM