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Front Endocrinol (Lausanne) 12, 678055

The carnitine pool as multidisease biomarker, crosstalk mediator, and therapeutic target The differences in the composition and levels of the carnitine pool in different organs reflect their unique metabolic states and health conditions, carnitine/acylcarnitine have the potential to serve as biomarkers for the occurrence and development of a variety of diseases

While high, uncontrolled glucagon action is problematic, controlled, balanced glucagon receptor agonism appears to unlock a different set of metabolic benefits

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Preclinical rodent studies with GLP-1 class drugs have identified a potential risk of thyroid C-cell tumours (medullary thyroid carcinoma)