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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

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The failure in these processes produces oxidation of proteins

Self-administering peptide combinations without bloodwork monitoring and clinical oversight is not responsible research practice

However, a potential limitation of the work is that other alternative sources of amino acids, including cysteine, may exist in the tumour interstitial fluid, and their relative contribution has not yet been defined