PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
Better outcomes with GLP-1s in those with diabetes and peripheral arterial disease July 29, 2026 Summary: In a propensity-matched observational study of 2,133 pairs of patients with type 2 diabetes and peripheral artery disease, those prescribed GLP-1 receptor agonists had lower five-year rates of death, hospitalization, revascularization, and amputation than those prescribed metformin
Grunvald adds
The Philippines FDA did issue a warning about unregulated high-dose IV glutathione being used for skin whitening, citing possible risks like kidney or nerve problems when misused
Silencing DKK1 has demonstrated the potential to inhibit tumor development in a CD8 + T cell-dependent approach, indicating its role in immune modulation
If you have a history of eating disorders, GLP-1 treatment requires close monitoring by a provider who understands both the medication and the eating disorder dynamics