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The article states that major clinical trials of semaglutide and tirzepatide have not identified depression as a common adverse effect
Are GLP-1s safe to take
However comparing GLP-1s to metformin is not straightforward, as individual treatment plans may vary and the choice of medication can depend on various factors
While semaglutide works mainly on blood sugar and appetite, it can also have effects on the brain, especially in areas related to hunger and reward
In previous clinical trials, semaglutide has demonstrated significant reductions in MACE, including CV-related death, non-fatal myocardial infarction, and non-fatal stroke [38,39,40, 42,43,44,45]
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