slc25a39 is necessary for mitochondrial glutathione import in mammalian cells concentration mitochondria Cellular Compartmentalization, Transport and Its Relevance Some Pathologies – slc25a39 is necessary for mitochondrial

This can leave mitochondrial membranes, enzymes and DNA more vulnerable to oxidative injury

Consistent with the above functional and biochemical findings, intracellular ROS levels assessed by DCFH-DA fluorescence staining showed that MAPKAPK2 overexpression markedly attenuated H2O2-induced ROS accumulation, reducing ROS levels by approximately 30%40% compared with the H 2 O 2 + vector group

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Judaki et al