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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

After several months of consistent treatment, blood tests often show lower homocysteine

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This means that even if you do have a vitamin B12 deficiency, your body will likely be able to compensate for this at least from a methylation perspective via your dietary choices