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Introduction Depression is one of the leading mental disorders, and the number of people with depression has reached approximately 280 million worldwide from World Health Organization (WHO) statistics, making it a major contributor to the overall global burden of diseases (World Health Organization, 2023a,b)

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Brain Sci 13(10):1475 Wray NR, Lee SH, Mehta D et al (2014) Research Review: Polygenic methods and their application to psychiatric traits

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Combining ipamorelin with CJC-1295, which is functionally similar to sermorelin, is a common strategy