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TRPM8 is expressed on trigeminal sensory neurons involved in migraine pain signaling and represents a biological pathway distinct from those targeted by existing migraine therapies, including calcitonin gene-related peptide (CGRP) receptor antagonists

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Stacking peptides is designed to induce synergy through combining complementary pathways

Studies involving participants with severe physical illnesses like cancer were excluded to maintain comparability

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She also suggests speaking to a behavioral health provider beforehand to screen for issues that could exacerbate mental health problems while on the medication, such as eating disorders or unmanaged mental health concerns