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In the STEP-1 clinical trial, non-diabetic patients taking 2.4 mg of semaglutide lost 14.6% of their body weight, compared to 2.4% with placebo

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Glucagon: driving energy expenditure and lipid oxidation Glucagon functions through glucagon receptors (GCGRs) expressed predominantly in the liver, where it promotes glycogenolysis and fatty acid oxidation [48]

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