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Tetrahydrobiopterin (BH 4 ) is an essential cofactor for eNOS required for efficient electron transfer during the synthases catalytic cycle (Crabtree et al., 2009a

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Maia LB, Maiti BK, Moura I, Moura JJ

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Next, the persulfide at Cys201 attacks the C4a position of FAD, whereas the sulfur on Cys379 is transferred to an external sulfur acceptor