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SURPASS-3 MRI, a sub-study of the phase-3 SURPASS-3 trial assessed tirzepatide administered once per week versus insulin degludec on liver fat content (LFC)

One of the biggest studies to draw attention looked at adults with overweight or obesity and established cardiovascular disease, but without diabetes

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Wegovy is a GLP-1 receptor agonist for chronic weight management, whilst escitalopram is an SSRI antidepressant

It enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways