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Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well ( 2.3.1 The dual role of CHAC1 in cancer CHAC1s function in cancer is complex and highly context-dependent
The liver orchestrates lignan metabolism, with cytochrome P450 enzymes (CYP3A4 and CYP2B1) catalyzing biotransformation into multiple metabolites (57)
Park J-Y, Kim JH, Kim YM, Jeong HJ, Kim DW, Park KH, Kwon H-J, Park S-J, Lee WS, Ryu YB
Dwivedi D, Megha K, Mishra R, Mandal PK
The glutathione-bound toxic substance can then be excreted in the urine, sweat, or feces.[ref] Glutathione S-transferase (GSTM1, GSTP1, etc) detoxification reactions Related article : GST Genetic Variants What depletes your glutathione levels
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