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Recently, the STEP-HFpEF trial enrolled 529 non-diabetic patients with HFpEF and obesity, who were randomly assigned to receive either once-weekly semaglutide (2.4 mg) or placebo for 52 weeks
The first strategy involves GLP-1RAs, which mimic the action of natural GLP-1 and activate its receptors
All of this is receptor-level characterisation in transfected cell systems and recombinant complexes, and none of it constitutes evidence of any effect in humans
doi: 10.1038/s41467-021-25364-2 84 YangJ.BrownM
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Maintaining a healthy lifestyle while taking GLP-1s is critical for successful weight loss
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