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Mice were 24 weeks old at the start of the study and were randomized based on body weight into study groups ( n = 8 per group) and mock-handled from day 4 to day 1

Additionally, a long-term extension study established that Vtamas effects were durable and its tolerability profile remained favorable over 48 weeks of follow-up

Diabetes Care 37 (10), 28642883 (2014)

The cell bodies of orexin expressing neurons are found in the lateral and posterior hypothalamic areas with axonal projections throughout the brain