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Of note, transcription of cyclin-dependent kinase inhibitor, p21 ( CDNK1A ) was significantly upregulated in response to GSTO1 knockdown while that of the cell cycle regulatory proteins cyclin D1 ( CCND1 ), cyclin E1 ( CCNE1 ), as well as Myc were found downregulated (GEO accession No

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Both lipoic acid and dihydrolipoic acid can directly scavenge (neutralize) physiologically relevant ROS and RNS in the test tube (reviewed in 3)