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However, if the criteria widened to target age-related diseases, not only will more younger people start taking them but the age range might expand
16 GLP-1RAs achieve sustained pharmacological effects by resisting degradation by DPP-4 in the body, consequently contributing to hyperglycemia and insulin resistance related to glucose metabolism, 17,18 lipid profile alterations, changes in fat composition, visceral fat accumulation, and obesity related to lipid metabolism, 1921 which constitute the systemic metabolic characteristics of interest in MASLD management
Longer and larger prospective studies are needed to inform clinical guidance about how this population can safely use GLP-1s
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