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At 24 weeks, retatrutide 12 mg delivers 17.5% body weight loss versus an estimated 12-13% for tirzepatide 15 mg

Semaglutide (Wegovy) : Similar to liraglutide, this GLP-1 agonist may also elevate heart rate modestly

While LBM loss appears to be less pronounced than FBM loss in many studies, the clinical significance of even modest reductions in skeletal muscle remains uncertain, particularly in older adults or individuals at risk of sarcopenia

Even her favorite wine, which usually tasted crisp and citrusy, seemed weirdly vegetal. Similar to Fraser, other users of Wegovy (known in its generic form as semaglutide), along with those of Ozempic (a form of semaglutide used to treat type 2 diabetes), Zepbound (known generically as tirzepatide) and other medications broadly called glucagonlike peptide 1 (GLP-1) receptor agonists, have described peculiar changes in the way food tastes

But the real-world concerns I hear every day are not hard to predict: How long do I have to stay on this? What happens if I stop? Will insurance keep paying? Can I afford this for years? Is there a better long-term alternative? Those are smart questions

This is thought to be related to higher levels of estrogen, which is stored in fat cells