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Interestingly, W-24 (106), a non-peptide GLP-1RA, has been reported to inhibit inflammatory pain by stimulating the spinal cord GLP-1R for the release of analgesic -endorphin

Semaglutide might be better for you if You have type 2 diabetes (additional blood sugar benefits) You prefer a medication with longer clinical history You want proven, consistent results Insurance covers semaglutide but not tirzepatide Tirzepatide might be better for you if You want potentially greater weight loss Youve tried semaglutide without optimal results You have both weight and blood sugar concerns You can tolerate potentially higher initial costs Both medications work best for people who Have a BMI of 30 or higher (or 27+ with weight-related health conditions) Are committed to lifestyle changes Can handle weekly injections Want non-surgical weight loss treatment

PMID 20020268

Resume work and most normal activities the same day

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