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Two estimands were employed to assess treatment efficacy from different perspectives and accounted for intercurrent events and missing data differently, as described in a previous publication 31

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Serious Adverse Events and Discontinuation Signals In TRANSCEND-T2D-1, Lilly reported adverse-event discontinuation rates of 2.2%, 4.5%, and 5.1% with retatrutide 4 mg, 9 mg, and 12 mg, compared with 0.0% with placebo [9]

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