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When a complete allose molecule coats the lower intestinal wall, these receptors, upon sensing its intense sweetness, immediately signal L cells to rapidly and profusely release GLP-1 into the bloodstream
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If a patient has achieved substantial weight loss on tirzepatide but has plateaued, providers might consider whether the modest additional benefit from orlistat justifies the added side effects and cost
Stay well-hydrated, especially if experiencing any gastrointestinal side effects