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It is plausible that GLP-1 agonists could decrease reward (i.e., pleasure) and cravings for addictive substances. Plausible, but not confirmed

Read more: To view or add a comment, sign in In early 2026, the FDA sent 30 warning letters to telehealth companies over how theyre marketing compounded GLP-1 drugs, calling out false or misleading claims and practices that may violate federal law

The experimental procedure was based on the protocol described by (Gregory and Pfaff 1971)

The two receptor mechanisms are complementary GHRH-R and GHS-R1a agonism synergize on GH release in paired secretagogue studies

Common side effects include: Nausea Vomiting Diarrhea Constipation Abdominal pain These are typically mild and lessen over time

To address these limitations and further evaluate the therapeutic potential of BCATi in an in vivo setting, we developed a mouse model of MMA, Mmut p.L690Ins/p.L690Ins , that closely mimics the human disease