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Berberine may affect gut bacteria and digestion to increase peptides associated with appetite (including GLP-1), and regulate genes and blood sugar production from the liver

Rubino DM, Greenway FL, Khalid U, ONeil PM, Rosenstock J, Srrig R, et al

LiXSObeidSKlingenbergRGencerBMachFRberLet al

Intrapatient changes in CT-Based body composition after initiation of semaglutide (Glucagon-Like Peptide-1 Receptor Agonist) therapy

Participants taking 1 mg per week of semaglutide lost about 14 pounds and lowered their A1c by 1.8 percentage points on average, while those taking 1.5 mg per week of dulaglutide lost an average 6.5 pounds and took 1.4 percentage points off their A1c

De Felice FG, Gonalves RA, Ferreira ST