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This study is a global, randomized, double-blind, placebo-controlled clinical trial (n=11000) aimed at evaluating the effectiveness and safety of Zilebesiran (300mg, subcutaneous injection, once every 6 months) combined with standard treatment (OC) compared to placebo combined with SOC in reducing the incidence of major cardiovascular adverse events (MACE) in hypertensive adult patients with diagnosed cardiovascular disease or poor blood pressure control at high risk of cardiovascular disease

Notably, FGF21 analogs have reduced insulin resistance or decreased liver fat in clinical trials 16,26

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